Sixth seed Richard Gasquet, the highest-ranked player left in the draw, was beaten by Robin Soderling in the quarter-finals of the Marseille Open.
Unseeded Swede Soderling beat home favourite Gasquet 6-1 7-6 (7-4) to earn a last-four clash against another Frenchman, Gilles Simon.
It was Soderling's second upset of the week, coming after he beat top seed Nikolay Davydenko in the first round.
"I was worn out," said Gasquet, who helped France beat Belgium 4-1 in the Davis Cup last weekend. "Before the match I did not have much hope."